Diabetes mellitus treatment, management and control with low level laser therapy

Ani aging effect
Summary of Qi-Light on Diabetes

Based on Traditional Chinese Medicine and scientific principles and studies, a light therapy (or phototherapy) method like that of Qi-Light based on intranasal blood irradiation, has a record of treating and controlling diabetes mellitus with related complications in the following ways:

  • At the insulin production stage, the method mitigates the factors that inhibit the production of insulin.
  • It helps cleanse the system of aging insulin receptor cells and improves insulin absorption.
  • It neutralizes the impact of diabetic complications such as neuropathy and retinopathy.
  • It reduces the sugar concentration in blood. No side effects are associated with the light therapy method.
Alternative medical therapy for diabetes

In treating diabetes, one of the key priciples of Traditional Chinese Medicine (TCM) is to "quicken the blood".[1] This is to improve blood circulation. Various Chinese medicinal herbs are usually recommended for treatment. Light therapy along the method of Qi-Light has bases in modern science, as discussed in the relevant page of this website. This argument is also supported by relevant scientific evidence discussed below.

Scientific principles and evidence behind this alternative approach to diabetes

There is an abundance of advice for the prevention, treatment, management and control of types 1 and 2 diabetes mellitus. The options include lifestyle, dietary changes and medications.

Theoretically, diabetes cannot be anticipated, prevented or cured. However, here we will discuss an alternative therapy using light that would sufficiently provide biostimulation to mitigate the onset of diabetes and regulate the biochemical substances to temporarily reduce blood sugar and addresses complications caused by diabete. It has been largely ignored in the West but light therapy has scientific bases along with a credible amount of evidence to address diabetes. Scientific data supports light therapy treatment of diabetes from different angles as follows:

  • Mitigate the complications of diabetic hemoconcentration (“thick blood” or high blood viscosity) by “thinning” the blood. This also improves blood flow/circulation that is necessary to perfuse substances that support insulin activity and reduce further diabetic related complications,
  • Catalyze substances that improve insulin acceptance by tissues,
  • Regulate substances that cause diabetes related complications.
Hemoconcentration is prevalent in diabetes

From our tests, diabetic subjects exhibit some measure of hemoconcentration or hyperviscosity, manifested as highly aggregated red blood cells (RBC) when the blood samples are examined under the microscope. See Figure 1 below. The exceptions are those that are on “blood thinning” medication such as anti-coagulants and antiplatelets for a cardiovascular conditions.

RBC aggregated

Figure 1: Hemoconcentration in blood sample of a pre-diabetic subject.

Hemoconcentration is neutralized with light therapy

In all the cases of diabetes and pre-diabetes, a single 25 minute treatment with Qi-Light reduces hemoconcentration / hyperviscosity / RBC aggregation. See Figure 2. This signals that light therapy applied in this manner treats the diabetes factors behind these manifestations.

RBC disaggregated

Figure 2: Hemoconcentration reduced by Qi-Light therapy

A picture of the Qi-Light device is shown in Figure 3 below.

qi light device

Figure3: Qi-Light device

Relationship between diabetes and red blood cell aggregation

A number of studies have suggested that the RBC in diabetic patients are rheologically (relating to blood flow) abnormal.[2] In diabetics RBC aggregation is frequently observed in retinal (tissue at the back of the eye) and conjunctival (relating to the clear membrane covering the front of the eye) venules (small blood vessels removing deoxygenated blood away from the tissues), and even arterioles (small blood vessels that carry oxygenated blood), under shear rates which normally produce an aggregated suspension of RBCs. The extent of RBC aggregation can be correlated to the appearance of retinopathy (disease of the retina) and neuropathy (disease of the nervous system) – both disease commonly identified with more advanced diabetes.[3]

The enhanced RBC aggregation has been attributed partially to elevations of a- and ß-globulins and fibrinogen levels. Skovsberg et al posulates that the usual abnormality of these plasma protein pattern probably accounts for the reported increases in plasma viscosity.[4] The authors have shown that the viscosity of whole blood in adults with diabetes is higher than for normal adults.

The influence of inflammation, cytokines and fibrinogen on diabetes and RBC aggregation

Diabetes and chronic inflammation are likewise found to be linked. It is common knowledge now that type-2-diabetes rates have risen alongside obesity numbers. The biochemical connection between obesity, diabetes and inflammation is that fat cells secrete inflammation-boosting proteins called cytokines. Hence, more fat equals more inflammation. Over time, too many circulating cytokines hamper the body’s ability to regulate insulin production.[5] The insulin imbalance sets the stage for type 2 diabetes. Here again the inflammation related to diabetes elevates fibrinogen levels, which then sets in RBC aggregation – which we observe in diabetic patients as a visible manifestation of the disease. More explanations.

Affecting blood flow dynamics and circulation

The cause of diabetes is not just a straight forward issue of insulin production, balance and resistance. Many complications of diabetes stem from damage to the microcirculation system, and evidence is emerging postulating that the manipulation of microvascular hemodynamics (blood flow dynamics and circulation in the blood capillary system) as the Qi-Light device does, may have therapeutic potential.[5]

An Argentinean study postulates that the microcirculation impairment caused by RBC aggregation could be a contributing factor to vascular disease and diabetes.[6] As in the Russian study cited above supporting the administration of light therapy to reduce the level of cholesterol, the same could be argued to mitigate the onset of diabetes - through the improvement of microcirculation.

Release of nitric oxide from red light

As previously mentioned above, inflammation caused by conditions such as obesity can result in cytokine-induced inhibition of insulin. In a study by Corbett et al the results indicate that nitric oxide (NO) mediates this condition and aid the release of insulin.[10]

Several studies suppport the expectation that light of the red spectrum as generated by Qi-Light to stimulate the release of nitric oxide.[11] So a device that performs like Qi-Light should help in mediating diabetic conditions.

Light therapy reduces sugar concentration, improves diabetic complictions

Indeed this argument is further supported by another Russian study. It found that with red low level laser irradiation of the blood, “figures of total cholesterol, LDL cholesterol and triglycerides decreased to their norm or its upper limits with simultaneous increase of alpha-lipoprotein. Sugar concentration in blood also decreased”. The researchers concluded that laser (light) therapy is an important component in the treatment of diabetes mellitus.[7]

Testing low level red light therapy irradiation under controlled conditions has produced the following outcomes: negative sensations in the lower limbs such as pain, sensitivity to cold, pain while walking, and conjunctival conditions improved.[12] Diabetic angiopathy (disease of blood vessels) of pelvic limbs improved after 2-3 sessions of treatment. Patients showed decrease or disappearance of pain, cramps and paresthesia (tingling and prickling sensation), “getting warmer” of limbs. By the end of the 9 month test period, symptoms of diabetic encephalopathy (disorder of the brain) and asthenia (loss of strength and energy) disappeared in all patients. Mood and sleep also improved. Fasting glycemia in type 2 diabetic patients decreased from 14.21± 0.85 mmol/l to 6,01± 0,35 mmol/l in 3 weeks. Fasting glycemia in type 1 diabetic patients reduced from 10.46±1.46 mmol/l to 7.45±1,04 mmol/l. Consequently, dosages of insulin and sugar-correcting medications have been considerably lowered. The results of ophthalmologic investigation demonstrated improved retinal blood circulation in patients with diabetic retinopathy. Patients of the control group did not show any improvement.Throughout the trial period, no side effect was also observed.[12]

In summary, although diabetes cannot be cured, continued treatment with light irradiation therapy appears to mitigate the complications of diabetes without the need for pharmacological drugs.

Biochemical and biological effects behind light therapy on diabetes

Type 2 diabetes results when cellular receptor sites have been altered and will not allow insulin to attach. A report by type 2 diabetes researcher Makela, presents the biochemical details of the occurrence of diabetes and consequential complications.[8] One factor that amplifies the toxicity of a diabetic condition is the elevated production of an enzyme, myeloperoxidase (MPO) due to various reasons. Irradiation of light at around 660nm (which is around that generated by Qi-Light) has the effect of inhibiting the production of MPO.

Irradiation of this light also stimulates macrophages (white blood cells in tissues) to release the enzyme superoxide dismutase (SOD – an anti-oxidative enzyme) which have the effect of improving diabetic conditions. The activity of cytochrome P450 (enzyme that breaks down toxins) and many other substrates are regulated, enabling the control of glucose and the breakdown of glycation end products (AGEs) to prevent the development of complications that arise out of diabetes.

Makela tested the above theory with the application of low level light of 660m wavelength on selected acupuncture points through the skin and observed positive results through the activities of the macrophages.[8] Theoretically the macrophages and enzymes are carried in the vascular networks and a method to irradiate the blood stream like that applied by the Q-Light method would be more efficacious.

Some alternative theories on the light therapy on diabetes border on the realm of quantum physics such as the light contributing an electron to damaged atoms and cells through the production of “soliton waves” and the more updated “scalar waves”. However there is a lack of sufficient scientific data and peer support for these theories.

Addressing the complications of diabetes

The main danger of diabetes is that too much glucose or blood sugar in the blood for a long time can cause diabetes problems/complications. This high blood glucose can damage many parts of the body, such as the heart, blood vessels, eyes, and kidneys. Heart and blood vessel (cardiovascular) disease can lead to heart attacks and strokes, the leading causes of death for people with diabetes. [13] Qi-Light with its intranasal light therapy can address cardiovascular diseases as extensively discussed in the relevant page.

Diabetes can make your blood cholesterol level too high. When cholesterol is too high, the insides of large blood vessels become narrowed or clogged (atherosclerosis). The issue of high blood cholesterol is also dealth with in the relevant page.

Progressive blurred vision is another diabetic complication and it can lead to blindness. It could be due to diabetic retinopathy (damage to a blood vessel in the retina), cataract (clouding of the eye’s lens) or glaucoma (increase in fluid pressure). As discussed earlier, light therapy applied to the blood has a positive impact on diabetic related diseases such as these through improved microcirculation. A study that applied intravenous blood irradiation with low level laser on diabetic patients demonstrated improved retinal blood flow in patients with diabetic retinopathy.[9]

Peripheral arterial disease (PAD), another diabetes complication, can happen when the openings in the blood vessels become narrow and the subject's legs and feet don’t get enough blood. One may feel pain in the legs during walking or exercising. Some people also have numbness or tingling in their feet or legs or have sores that heal slowly. Intervention to this complication can come from better blood circulation out of regular therapy from Qi-Light.

Other complications mentioned earlier are the various diabetes related diseases of the nervous and vascular systems and it is expected that irradiation of the blood would be effective in the same way, as discussed more extensively in the other pages of this website.

Doing it with the Qi-Light therapy device

The Qi-Light from RadiantLife, pictured below in Figure 4 is a hand-held portable non-invasive blood irradiation device in use.

Using intranasal device

Figure 4: Qi-Light device in use

In using this unique device, the nose-clip applicator delivers managed light of the red spectrum into the vascular rich capillary bed in the nasal cavity for 25 minutes, as illustrated below. Any adult can self-administer it without supervision. There is no feeling of any noticeable discomfort.

The method is non-invasive and requires no special training to use.

More evidence captured in video can be viewed here.


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References
  1. D X Yan, "Aging & Blood Stasis: A New TCM Approach" Blue Poppy Press 1995:pp 192-196.
  2. D E McMillan, “Reduced erythrocyte deformability and vascular pathology”, In: Erythrocyte Mechanics and Blood Flow, G R Cokelet, H J Meiselman, D E Brooks (Eds.), Alan R Liss, New York 1980: pp 211-218.
  3. J Ditzel, “Haemorheological factors in the development of diabetic micro-angiopathy”, Br. J. Opthal. 1967;51: p 793.
  4. F Skovborg, A V Nielsen, J Schlichtkrull, J Ditzel. “Blood viscosity in diabetic patients”, Lancet i 1966: p 129.
  5. J E Tooke, “Microcirculation and diabetes”, British Medical Bulletin 45 (1989), pp 206-223.
  6. P Foresto, M D’Arrigo, L Carreras, R E Cuezzo, J Valverde, R Rasia, “Evaluation of red blood cell aggregation in diabetes by computerized image analysis”, Medicina (Bueno Aires) 2000, 60, pp 570-572.
  7. T V Kovalyova, A V Farvayeva, L T Pimenov, S M Denisov, “Dynamics of hyperlipidemia and peripheral blood flow in patients with diabetes mellitus after the course of combined laser therapy in ambulatory polyclinic conditions”, Medical Academy, 2nd Municipal Out-Patient Department, Izhevsk, RF Russian Medical University, 13th State Clinic Hospital, Moscow, RF.
  8. A M Makela. "Theoretical backgrounds for light applications in diabetes", Paper presented at Laser Florence 2004. Full paper is available here.
  9. T V Kovalyova, “Ambulatory application of combined laser therapy in patients with diabetes mellitus and dyslipidemia”, Laser Partner, 17.5.2002. Out-patient Department of the 2nd Municipal Clinical Hospital, Izhevsk, Russia. Online: http://www.laserpartner.org/lasp/web/en/2002/0046.htm.
  10. J A Corbett, M A Sweetland, J L Wang, J R Lancaster Jr, M L McDaniel. " Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans", Proceedings of the National Academy of Sciences of the United States of America (PNAS) 1993; 90(5): pp 1731-1735.
  11. Example, A Lindgård, L M Hultén, L Svensson, B Soussi, "Irradiation at 634 nm releases nitric oxide from human monocytes", Lasers in Medical Science 2007; 27(1): pp 30-36.
  12. T V Kovalyova, "Ambulatory Application of Combined Laser Therapy in Patients with Diabetes Mellitus and Dyslipidemia", Laser Partner.2002; 46.
  13. National Diabetes Information Clearing House (NDIC), "Prevent diabetes problems: Keep your heart and blood pressure healthy", Webpage on September 19, 2010.
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